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"Superstructures of protein-based amyloid nanofibrils as a scaffold material for SERS platforms"
Warsaw University, Department of Chemistry, Pasteura 1, Warsaw 02-093, Poland
Nanostructuring of noble metal (such as Au, or Ag) surfaces with biomorphic templates facilitates variety of applications of surface enhanced Raman scattering (SERS). On the other hand, there is a growing interest in possible applications of amyloid fibrils – linear, beta-sheet-rich aggregates of misfolded protein molecules, studied so-far mostly in the context of degenerative disorders such as Alzheimer’s disease. Here we show that the newly reported insulin amyloid superstructures  may be employed as stable nanoscaffolds for metallic Au films providing an effective substrate for surface enhanced Raman scattering on covalently bound aromatic molecules . The self-assembled superstructures of insulin fibrils are capable of templating nanopatterns in sputtered Au layers without overlapping the SERS spectra of the Raman scatterer with vibrational bands stemming from the protein.
 Loksztejn A, Dzwolak W, J. Mol. Biol. 395 (2010) 643–655.
 Wojcik S, Babenko V, Dzwolak W, Langmuir 26 (2010) 18303–18307.
Presentation: Invited oral at Nano-Biotechnologia PL, by Wojciech Dzwolak
See On-line Journal of Nano-Biotechnologia PL
Submitted: 2012-07-15 03:20 Revised: 2012-08-16 13:21