Paclitaxel (PACL) is one of the most widely used anti-cancer chemotherapeutic drugs. It`s usually applied to treat patients with lung, ovarian, breast, head and neck cancers. However, therapeutics efficacy and safety of drugs administered by conventional methods is limited. In the recent years, considerable attention has been focused on the research of the polymeric drug delivery systems. Polymeric conjugates have been extensively studied and applied as promising delivery systems to augment therapeutic efficacy of chemotherapeutic agents in the treatment of cancer. Some problems, however, such as allergic reactions, heart and blood vessel effects and infections have limited their use due to a low white blood cell count, hair loss, joint and muscle pain, irritation at the injection site, a low red blood cell count, mouth or lip sores, numbness, tingling or burning in the hands and/or feet, stomach upset and diarrhea as well as decrease in urine output and/or swelling of the hands, face or feet [1-3].

The aim of the present study is to synthesize polyester-PACL and poly(ester-carbonate)-PACL conjugateswith different molecular weights and characterization of their physicochemical properties. The degree of degradation of the macromolecular conjugates was tested in vitro under different conditions.

We believe that the obtained polyester and poly(ester-carbonate) conjugates of PACL can find practical applications as effective implantation drug delivery systems.

References:

[1] R. Panchagnula, Review: pharmaceutical aspects of paclitaxel, Int. J. Pharm. 172 (1998) 1-15.

[2] C.M. Spencer, D. Faulds, Paclitaxel e a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer, Drugs 48 (1994) 794-847.

[3] R.B. Greenwald, C.W. Gibert, A. Pendri, C.D. Conover, J. Xia, A. Martinez, Drug delivery systems: water soluble taxol 20-poly(ethylene glycol) ester prodrugs design and in vivo effectiveness, J. Med. Chem. 39 (1996) 424-431.

The work was supported by the research program (ProjectMNiSzW-0451/B/H03/2010/39, N N209 045139) of the Ministry of Science and Higher Education in Poland.

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