Among different nanomaterials, gold nanoparticles are especially interesting for biocatalysis due to great affinity of gold to thiols and amino groups, which are present in enzymes. Such interactions may cause changes in a structure of an enzyme and modify its substrate specificity. In literature, there is no information about influence of gold nanoparticles on enzyme stereoselectivity. Therefore systematic studies were performed to verify this phenomenon. Selected enzymes were immobilized on gold nanoparticles using different protocols. Obtained bionanocatalysts were used in a model reaction. Reaction progress was monitored using standard procedure and enantioselectivity was determined. The influence of bionanocatalysts structure on the stereochemical course of the reaction studied will be discussed.
Acknowledgments: This work was spported by project ”Biotransformations for pharmaceutical and cosmetics industry” No. POIG.01.03.01-00-158/09-01 part-financed by the European Union within the European Regional Development Fund.

1. PRESENTATION: Studies towards stereoselective bionanocatalysis on gold nanoparticles, Microsoft Office Document, 1MB

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