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Synthesis and optical properties of ultrasmall inorganic optical markers based on lanthanides emission for bio-medical applications

Artur Podhorodecki ,  Mateusz Banski ,  Agnieszka Noculak ,  Bartlomiej Sojka ,  J. Misiewicz 

Wroclaw University of Technology, Institute of Physics, Wybrzeże Wyspiańskiego 27, Wrocław 50-370, Poland

Introducing to medicine and biology concept of optical markers in tremendous way has changed the recent status of these two important disciplines. This was mainly due to strong development in imaging techniques which recently allow us to investigate both static as well dynamic properties of living cells, their components and their interactions with external factors.  

Recently used molecular markers including organic dyes, fluorescent proteins or chelates containing lanthanide ions have several significant limitations. One of the alternatives for molecular markers are inorganic quantum dots (ie. CdSe, CdS) which are recently commonly used in many academic works. However, even if they are much better from physico-chemical point of view, from the application point of view at this moment they are rather useless mainly because of their high risk of toxicity. One of the solution combining advantages of both concepts is to make nontoxic inorganic nanocrystals doped by lanthanide ions.

In this work, we will present optical results obtained for NaYF4, NaGdF4 and GdF nanocrystals doped by different lanthanide ions (Eu, Tb, Nd, Tm, Yb). The aim of this work was to design and to synthesize these markers and to understand physical processes responsible for their emission/excitation and to optimize these processes to the physical limits. Additionally, potential use of such nanocrystals in nano-bio medicine will be discussed.


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Presentation: Oral at Nano-Biotechnologia PL, by Artur Podhorodecki
See On-line Journal of Nano-Biotechnologia PL

Submitted: 2012-05-29 13:51
Revised:   2012-06-11 12:22