Modified release tablets nowadays are very popular form of introduction of active substances for medicinal treatment. The main advantage of these forms is much simpler dosing scheme with only one tablet per a day instead of 2-4 in case of normal drug product. The benefits of modified release drug product requires more complex multistep manufacturing process and moreover an understanding of functionality of human digestion system and changes of conditions during digestion process.The fundamental differences of modified and normal release of active substances are presented with visualization of both variants on graphs.

This article shows the mechanism for modifying release of active substance and present common technical procedure for manufacturing of modified release drug product with regards to excipients used and manufacturing process. All information are supplemented with graphs and pictures which helps to understand the principle of modified release drug product.

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