Epilepsy is a disease of different cerebral disorders of central nervous system, and it is characterized by paroxysmal, excessive and synchronous discharges of large numbers of neurons. In fact, epilepsy is the third most frequent neurological disorder and affects patients of different age groups and sex. [1].

Searching for the new safer and more effective antiepileptic drug, we modify the structure of available one – phenytoin, which has already known to possess a useful mechanism of action. As a continuation of our work involving five-member heterocyclic anticonvulsants [2], we have designed and synthesized new 5-(cyclo)alkyl-5-phenylimidazolidine-2,4-dione ring with arylpiperazinylpropyl moiety. The major modifications of newly synthesized compounds were change of substituent at position 5 of hydantoin and elongation of linker between heterocyclic ring and arylpiperazine fragment, to three methylene units.

The investigated compounds were prepared in three step process, in which cyclization of hydantoin ring followed by alkylation with 1-bromo-3-chloropropan and condensation with appropriate arylpierazine moiety.

The compounds were evaluated for their anticonvulsant properties within the Antiepileptic Drug Development Program, by testing procedures, which have been described earlier [3].

This work was supported by the Polish MNiSW grant No N N405 298536

1. Khan H.N., Kulsoom S., Rashid H.”Ligand based pharmacophore model development for the identification of novel antiepileptic compounds” Epilepsy Res., 98, 2012, 62-71

2. Bytrus H., Obniska J., Czopek A., Kamiński K., Pawłowski M. “Synthesis and anticonvulsant activity of new N-Mannich bases derived from 5-cyclopropyl-5-phenyl- and 5-cyclopropyl-5-(4-chloro- phenyl)-imidazolidine-2,4-diones” Bioorg. Med Chem. Lett., 19, 2011, 6149-6156

3. Kupferberg, H.J. Epilepsia, 30, (suppl.), 51-56, 1989.

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