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Advantages and frontiers of Molecularly Imprinted Polymers – from fundamentals to application

Bartłomiej Wasiniak ,  Jerzy P. Lukaszewicz 

Nicolaus Copernicus University, Faculty of Chemistry (WChUMk), Gagarina 7, Toruń 87-100, Poland


In recent years, solid phase microextraction (SPME) has been applied widely to the analysis of environmental, food, biological and pharmaceutical samples. Compared with the conventional extraction techniques SPME is simple, sensitive, time efficient, solvent-free, and compatible with the analytical separation systems such as gas chromatography (GC), GC – mass spectrometry or high-performance liquid chromatography (HPLC). In present days new kind of sorbents are being developed and applied for achieving better sorption efficiency and higher selectivity. One of these kind of sorbents can be molecularly imprinted polymers (MIP’S).

Molecular imprinting is a technique to prepare molecular recognition materials. It has shown an accepted application prospect in many fields such as materials of solid-phase extraction, simulated enzyme catalysis, chemical sensors or membrane separations. MIP is quite suitable as a material of SPME fibre coating because of  high selectivity, chemical stability and easy preparation.  

In this research  molecularly imprinted polymer sorption material which can be later used for SPME improvement were prepared. In first step non-molecularly imprinted polymer was prepared. For this six different solvents such as acetonitrile, n-heksane, dimethylforamide,dichloromethane  or chloroform were used. As functional monomer methacrylic acid (MAA) was used. Crosslinker agent was ethylene glycol dimethacrylate (EGDMA). As polymerization initiator azo(bis)-isobutyronitrile (AIBN), benzoil peroxide, hydrogen peroxide, ammonium sulfate peroxide and g-radiation were used. During the synthesis different sorbents were produced. Further the same syntheses used additionally as the template ibuprofen were done. In this step molecularly imprinted sorption material (MIP) was prepared. Thermal stability of all the samples was checked by thermal analysis. Pore sizes and BET surface were characterized by sorption of nitrogen. Also the homogeneity and structure of surface of prepared materials was examined using scanning electron microscopy.


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Related papers

Presentation: Short communication at SMCBS'2011 International Workshop, by Bartłomiej Wasiniak
See On-line Journal of SMCBS'2011 International Workshop

Submitted: 2011-09-26 13:59
Revised:   2011-09-26 13:59