Cost and productivity of pharmaceutical quality-control laboratories is of utmost interest for most, if not all, of today's laboratory managers. In a pursuit of speed and excellence many of them moved into modern techniques, such as discussed here UPLC.

Comparison of HPLC and UPLC using Flutamide (API) as an example is presented. Analyses were performed simultaneously by means of HPLC (Waters Alliance 2695) and UPLC (Waters Acquity). Columns used in the study were Phenomenex Luna C18(2) and Waters Acquity BEH C18 respectively. HPLC method was scaled down to UPLC and then the parameters were assessed. No significant loss of method key indicators such as resolution between compounds (R_s) was observed. Moreover it was noticed that sensitivity expressed by signal to noise ratio (s/n) was higher for UPLC. Still the biggest advantage of UPLC over HPLC as shown here is conservation of time and resources which are directly proportional to laboratory efficiency and profitability.

Presented results clearly show the way which quality control laboratories should choose if they are serious about their competitiveness on the market. In contemporary world where more and more laboratories are diving into UPLC/UHPLC. One cannot stay ignorant or will be left behind.

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