The aim of the present study is to evaluate the pharmacokinetic of T and its major metabolites M1, M2 and M5 after single oral administration of a SR tablet and rectal suppositories in dogs (4-6 mg·kg^{-1 m.c.).} The plasma concentration data after SR-tablet and rectal administration were fitted on the basis of mono- and non- compartmental model, respectively. T plasma concentration after SR tablet administration, was quantitatively detected in three dogs, M1 was quantized only in one dog while M2 and M5 were quantized in all the dogs. T showed median values of C_max, T_max and T_1/2 of 0.04 (0.17-0.02) mg·mL^-1, 3 (4-2) and 1.88 (2.21-1.44) hours, respectively. M5 showed median values of C_max, T_max and T_1/2 of 0.1 (0.19-0.09) mg·mL^-1, 2 (3-1) and 4.23 (6.58-1.85) hours, respectively. M2 showed median values of C_max, T_max and T_1/2 of 0.22 (0.33-0.08) mg·mL^-1, 4 (7-3) and 4.49 (6.39-1.57) hours, respectively. Following rectal administration, T was detected from 5 minutes up to 10 h in smaller amount than M5 and M2. T median value of C_max was 0.14±0.06 µg·mL^{-1 in 0.56±0.41 h (T}_max). K₀₁ t_1/2 and K₁₀ t_1/2 were 0.27±0.25 h and 2.24±1.82h, respectively. T/M5 and T/M2 ratios were 0.48-0.09 and 0.9-0.13, respectively. M1 was detectable from 5 min up to 2 h showing low values (0.028-0.007 mg·mL^-1). The present findings suggest oral SR tablet and suppository rectal formulation has similar pharmacokinetic behavior could not has suitable pharmacokinetic characteristics to be administered once-a-day as an effective and safe treatment for pain in the dog.

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