The subgroup of DNA repair enzymes known as DNA photolyases are well known for their light-elicited catalytic activity which repairs ultraviolet radiation-generated cyclobutane pyrimidine dimers (CPD) in DNA. In this mechanism, DNA photolyase absorbs blue light which elicits a hypothesized single electron transfer (SET) event from the flavin adenine dinucleotide (FAD) cofactor in DNA photolyase to the bound CPD- containing DNA. The electron transfer results in the chemical separation of the pyrimidine bases and the electron transfers back to the FAD cofactor. In this communication, preliminary models for the use of DNA photolyase SET in bioelectronic sensing are discussed. Experimental evidence that suggests engineered DNA photolyase has DNA repair activity is reported. Models regarding the binding of DNA photolyase to conducting and semiconducting electrodes are discussed.

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