Introduction: traumatism and orthopaedic diseases cause huge damage to modern society. Annually more than 12 million men get hurt. More than 10 million men suffer from orthopaedic diseases. The diseases of bone tissue are originally different pathologic conditions, which become apparent with bone structure disturbance. The integral index of bone tissue metabolic activity is processes of active remodeling and renovation of bone structures, which continue the whole life. On the one hand, these processes are an important mechanism of maintenance of mineral homeostasis; on the other hand, they provide structural bone adaptation to changing conditions of functioning. The process of bone tissue remodeling is a mechanism directed on preservation of homeostasis, having a high sensitivity to different regulatory, supervisory mechanisms, as well as endogenous and exogenous influences. The most actual direction nowadays is detection and investigation of the main pathogenetic component of bone tissue pathology (both hereditary induced and multifactorial pathology) and search for ways of leading pathologic sign correction based hereon.

From theoretical point of view, the relevance of the work in this direction is determined with necessity to get fundamentally new concepts of aetiology and pathogenesis of musculoskeletal systemdiseases, as a complex multifactorial phenotype of individual. At practical perspectives, importance of investigation is determined with a necessity of development and acquisition of new medical materials for treatment of complex orthopaedic pathology.

1. FULLTEXT: Molecular-genetic criteria of efficacy of the use of bioactive nanomaterials in the field of traumatology and orthopaedy., Microsoft Office Document, 0MB

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