During the past two decades, significant advances have been made in the area of controlled release of bioactive substances so that now several well-known controlled release products are commercially available for the delivery of a variety of compounds useful in pharmaceutical, agricultural and veterinary domanis [1-3]
It is well known the use of polymers as carrying matrix of bioactive substances with application in biomedical field. In our previous studies [4-6] were presented our results concerning possibilities of polymer matrices obtainment in order of coupling bioactive substances.
The aim of this work is to couple the codeine onto polymeric structures obtained through polymerization and respectively copolymerization of methyl methacrylate (MMA) itself or with 2,3-epoxypropyl methacylate (GMA).
Copolymers are regarded as preactivated polymers owing to the presence of the functional groups susceptible to undergo reactions with amines, carboxylic, anhydrides and hydroxyl groups as well to perform supplementary physical linkages.

The drug release profiles have been established using UV spectra. The rate of drug release is lower higher is content of functional groups in polymer matrix.

References
1. Stevenson CL, Theeuwes F, Wright JC,Wise D, ed., Handbook of Pharmaceutical Controlled Release Technology. New York, NY: Marcel Dekker; 2000: 225-253.
2. Hermans JR, Van Essen H, Struijker-Boudier H, Johnson RM, Theeuwes F, Smits J Pharmacol Exp Ther. 301 (2002), 672.
3. Ramýrez LP, Landfester K, Macromol. Chem. Phys., 204, (2003), 2
4. Nita LE, Chiriac AP, Popescu, M, Vasile C, Proceedings of the Conference Tim Phys 2003.
5. Chiriac AP, Nazare (Nita) LE, Proceedings of the 12th Romanian International Conference on Chemistry and Chemical Engineering, Bucureşti, 13-15 September 2001, p. 380-385.
6. Chiriac AP, Nazare (Nita) LE, Proceedings of the 12th Romanian International Conference on Chemistry and Chemical Engineerings, Bucureşti, 13-1
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