Synthetic biodegradable aliphatic polyesters are widely used in biomedical applications because of their susceptibility to hydrolytic degradation [1]. In the last decade the intense investigation on the injectable, biodegradable bone cements based on poly(1,2-propylene fumarate) (PPF) was conducted [2,3]. Liquid composition of a polyester and a vinyl or methacrylic monomer can be cured in a site of application and provide temporary structural support to bone tissue. Similar idea was realized by us recently with use of poly(3-allyloxy-1,2-propylene succinate)4].
However, relatively high hydrophobicity of these materials slow down their hydrolytic degradation. In order to increase their susceptibility to hydrolytic degradation, a part of methyl methacrylate (MMA) comonomer was replaced by hydrophilic oligo(ethylene glycol) dimethacrylates (OEGDMA).
The influence of the composition of liquid resin (MMA:OEGDMA ratio) and of the length of the oxyethylene chains in dimethacrylates on curing process (setting time, peak temperature) as well as on selected properties of cured materials (hydrophilicity, hardness, compressive strength) was investigated. Both variables appeared to influence hydrophilicity of cured resins. Generally increasing hydrophilicity was accompanied with decreasing peak temperature, hardness, stiffness and compressive strength.

References
[1] Hasirci, V; Lewandrowski, K; Gresser, J.D; Wise, D.L; Trantolo, D.J; J.
Biotech. 2001, 86, 135.
[2] Domb, A.J; Manor, N; Elmalak, O; Biomaterials 1996, 17, 411.
[3] He, S; Timmer, M.D; Yaszemski, M.J; Yasko, A.W; Engel, P.S;
Mikos, A.G. Polymer 2001,42, 1251.
[4] Łukaszczyk, J; Jaszcz, K; React.Funct.Polymers, 2000, 43, 25.

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