Magnetic Biomimetic Scaffolds for Bone Tissue Engineering

Valentin A. Dediu 1Nathalie Bock 1Alberto Riminucci 1Chiara Dionigi 1Alessandro Russo 2Anna Tampieri 3Elena Landi 3Vitaly Goranov 4Maurilio Marcacci 2

1. Istituto per lo Studio dei Materiali Nanostrutturati (ISMN-CNR), Gobetti 101, Bologna 40129, Italy
2. Istituti Ortopedici Rizzoli, Laboratorio di Biomeccanica (IOR), Via di Barbiano 1/10, Bologna 40136, Italy
3. CNR-ISTEC, Institute of Science and Technology for Ceramics, Via Granarolo 64, Faenza 48018, Italy
4. Belarusian State Medical University, Minsk 1111, Belarus

Abstract

The use of scaffolds for tissue engineering is increasing due to their efficacy in helping the body rebuild damaged tissue. One of the current issues concerning this technique is how to improve the re-growth of damaged tissue by supplying growth factors; these have to be readily available to the live tissue that is growing in the scaffold. In the present work we address this problem by magnetizing the scaffolds. We show an example of our magnetizing technique on a bone graft substitute, which is used to replace damaged or diseased bone tissue. The susceptibility of the scaffold is sufficiently high that, if placed in a magnetic field, it acts as magnet. In our vision this will allow growth factors, which will be attached to magnetic nanoparticles, to be attracted by the scaffold and hence be available to the growing live tissue.

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Presentation: Oral at E-MRS Fall Meeting 2009, Symposium E, by Alberto Riminucci
See On-line Journal of E-MRS Fall Meeting 2009

Submitted: 2009-05-22 21:25
Revised:   2009-06-12 14:40
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