Instant Glucose Sensing Using the AD5933 Impedance Converter

Olga Korostynska Khalil Arshak 1Arshak Arous Shane Fitzpatrick 

1. University of Limerick (UL), Plassey Technological Park, Limerick 02098, Ireland

Abstract

Diabetes is a metabolic disorder, which results from insulin deficiency and hyperglycemia and is reflected by blood glucose concentrations being outside the normal range of 80-120 mg/dL (4.4-6.6 mM). The novel system is presented that utilises change in the value of impedance as an instant indicator of the glucose level of the solution, brought in contact with a sensor. The glucose sensor was developed using the enzyme glucose oxidase (GOx) immobilized within the poly(o-Phenylenediamine) (PPD). O-Phenylenediamine (o-PD) was prepared in an acetate buffer solution with pH5 and then mixed with GOx. The resultant GOx/o-PD mixture was deposited onto Au thick film interdigitated electrodes and electrochemical immobilization of the enzyme was performed using the bulk electrolysis with coulmetry technique at 3 V for 900 s.

Through a catalytic enzymatic reaction between glucose and glucose oxidase the biosensor generates hydrogen peroxide and its response therefore is based on the electrochemical oxidation of H2O2 [1]. The electrochemical formation of polymer films enables to make a glucose sensor with a controlled thickness, which is reproducible and could be miniaturized.

The sensor was connected to the Analog devices AD5933 impedance converter system, which measured a change in impedance when different glucose concentrations were deposited onto the sensor within 1-7 mM glucose range.

The well-manifested change in the value of capacitances is directly related to the concentration of the glucose in the solution being tested. Moreover, the response of the sensors to the glucose change was in the order of 10 s, similarly to [2].

[1] S. Cosnier et al, J. Electroanalytical Chemistry 469(2), pp. 176-181, 1999.

[2] O. Korostynska et al, Proc. IEEE SAS-2009, pp. 34-37.

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Presentation: Poster at E-MRS Fall Meeting 2009, Symposium F, by Khalil Arshak
See On-line Journal of E-MRS Fall Meeting 2009

Submitted: 2009-05-21 18:36
Revised:   2009-06-30 21:07
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