Engineering biomaterials by controlling recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes. Design and synthesis of artificial molecular structures capable of specific molecular recognition of biological molecules leads to biomimetic materials. Biomimetic configurational imprinting and microimprinting techniques, which create stereo-specific three-dimensional binding cavities based on a biological compound of interest, produce these biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering devices.

We present new developments of particular interest to the field that include recognition of undesirable biologicals, nano-scale patterning and recognition of proteins, site specific interaction with tissues, etc. Macromolecular networks with precise chemical architecture are prepared that possess enhanced mechanical, thermal, and recognition properties compared to their biological counterparts.

We have been successful in synthesizing novel glucose-binding molecules based on non-covalent directed interactions formed via molecular imprinting techniques within aqueous media. Numerous polymer systems were identified. Of particular importance in our polymer design is the network morphology, which spatially varies in crosslinking density (microporous and macroporous regions). Emphasis has also been placed on fundamental studies regarding the specific recognition event needed to produce a spatially defined recognition site. By tailoring the polymer gel structure composition, effective recognition sites can be created in polymer gels.

We have used micropatterning techniques for the preparation of synthetic polymer films with highly specific molecular recognition capabilities. We present recent data on their use as recognitive protein delivery systems.
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