Nanomedicine is the application of nanotechnology to the diagnosis and treatment of human disease. This discipline has the potential to change medical science dramatically, as demonstrated, for example, by an innovation in cancer imaging that uses novel diagnostic agents synthesized from nanoparticles. We are conducting research on cluster-based materials for future medical applications. The design of a multifunctional photosensitive particle that is stable and highly efficient will be key to this novel medical application and in the photodynamic treatment (PDT), especially. Three consecutive processes occur during the PDT treatment: initial consumption of oxygen through the photodynamic process; pathophysologic alterations in regional blood supply (hypoxia) and total vascular occlusion (ischemia). The effect of a new drug as TSPP-Sil-TiO₂ was studied in this paper. By coupling with TiO₂, TSPP is loosing the proper absorption bands, due to the chemical bonds SO₂-NH, present in the new synthesized system. The UV-Vis spectrum of the new system indicates J-aggregate form suitable for biomedical applications. The particle size and the morphology of TSPP-Sil-TiO₂ nanoparticles in acrylate matrix were investigated with AFM. The images of TSPP-Sil-TiO₂ nanoparticles in polymer matrix have been compared with TiO₂ nanoparticles alone. We implanted cancer cells under the skin of mice to cause tumors to form. When the size of the tumor grew to about 0.5 cm, it was injected a solution containing fine particles of TSPP-Sil-TiO₂. After 2 or 3 days, were cut open the skin to expose the tumor and irradiated it. The treatment clearly inhibited the tumor growth. A further marked antineoplastic effect was obtained.

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1. Phase Evolution Induced by Polypyrrole in Iron Oxide - Polypyrrole Nanocomposite