The porous calcium phosphate scaffolds with defined pore-channel interconnectivity were successfully prepared via negative replica method. The internal channel architecture was achieved using a water-insoluble polyurethane sponge. This material is thermally decomposable into gaseous residues. The PU sponge was first filled with aqueous slurry of biphasic calcium phosphate material containing pore forming agent. After drying at room temperature, a heat treatment was employed to remove all organic material. The bodies were finally sintered at the temperature of 1200°C. The phase composition and chemical structure of bodies were determined by X-ray diffraction (XRD) and FT-IR methods. Scanning electron microscopy (SEM) was used to study the pore size and distribution and pore-pore and pore-channel interconnectivity. The scaffold bodies were principally composed of HA and β-TCP with some traces of α-TCP. No residue of polymer replica or pore agent was identified. The scaffolds contained an interconnected pore-pore and pore-channel structure with a pore size less than 500 μm. The company of desired phase composition and pore-channel structure increases the hope for the production of more effective biodegradable scaffolds for hard tissue engineering.

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