Development of FexO/chitosan meso-porous “nano-rise” for organ-specific drug delivery vessels

Oleg Vasylkiv ,  Hanna Borodianska ,  Taras Kolodiazhnyi 

National Institute of Material Science (NIMS), Tsukuba, Japan

Abstract

The size dependent properties and biocompatibility of magnetic nano-FexO are extremely promising for assembling of the drug delivery vessels. Drug delivery vessels should provide minimally invasive solutions to achieving organ-specific delivery, minimize toxic side effects, and signify efficiency of drugs (including chemotherapeutic agents, and gene therapies) to the pathologic tissues. We report on the engineering of rice seeds-like iron oxide-based nanoaggregates uniformly covered with chitosan and its physical properties. Nano-aggregates of highly ordered 7-12 nm crystallites with exact composition are shown to become stable and chemically inert drug carriers. Advanced features of FexO –based nanoseeds will allow their use as new reliable and effective targeted delivery media instead of standard therapeutical treatment. Magnetic properties of seed-like FexO/chitosan nanocomposites including magnetic moment, saturation magnetization, coercive field and remanence magnetization of FexO were studied in the temperature range of 10 – 400 K.

 

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Presentation: Oral at E-MRS Fall Meeting 2008, Symposium F, by Oleg Vasylkiv
See On-line Journal of E-MRS Fall Meeting 2008

Submitted: 2008-05-16 09:22
Revised:   2009-06-07 00:48