Environmentally responsive hydrogels are very attractive for applications in sustained and /or targeted drug delivery systems. As the release of drugs is related to the swelling behavior of hydrogels, the swelling kinetic studies become of great importance to appreciate the release kinetic from hydrogels matrices.

Hydrogels with high performance properties have been prepared from N-isopropyl amide (NIPAAm) and sodium alginate, crosslinked with N, N`-methylene- bis-(acrylamide) (MBAAm).

This study is focused on the investigation of swelling and drug release kinetics, completed by morphological studies.

The kinetic parameters of the swelling performed at different temperatures and pHs for hydrogels samples with different mixing ratios of the components and various crosslinking degrees have been evaluated and  showed  their dual responsive behavior (under temperature and pH changes). The results obtained by swelling kinetics investigation showed the decrease of the swelling rate constant with increasing temperature and increase with the alginate content in the samples.

The drug release kinetic study from the prepared hydrogel matrices was performed in twice-distilled water and ethanol for bioactive agents as vanillin and ketoprofen, respectively. An increase of alginate content results in a slower rate and smaller percentage of vanillin and ketoprofen released. The ketoprofen release behavior fitted with case II of transport and vanillin release behavior fitted with an anomalous transport of drugs.  The values of  k decreased by increasing  ethanol quantity in case of  75/25 NIPAAm/alginate hydrogels and decreased also by increasing content of alginate in hydrogels with various compositions.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/15794 must be provided.

1. Architecture and composition influence on the properties of some smart polymeric materials designed as matrices in drug delivery systems
2. Nanocomposites based on montmorillonite/acrylic copolymers for aqueous coating of soft surfaces
3. Characterisation of the Chitosan/layered silicate nanocomposites