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The porous ceramic grafting material 

Tatyana M. Ulyanova 1L.V. Titova 1V.L. Evtukhov 2

1. Institute of General and Inorganic Chemistry of NAS of Belarus (IGIC), Surganov str., 9, Minsk 220072, Belarus
2. Belarusian State Medical University, Minsk 1111, Belarus

Abstract

The preparation of a biocompatible, slowly resolved material and its replacement by the living bone tissue due to natural regeneration of the cells of bone substance is a significant task. The present work is devoted to preparing a porous grafting ceramic material and to performing medical-biological experiments on it. Samples of porous implants were fabricated from natural raw material containing mineral and organic components. Heat treatment was made within a special step-by-step regime involving isothermal annealing. Moulding and mechanical processing were conducted at certain stages. For the influence of the heat treatment temperature on the structure and properties of porous ceramics to be studied, the implant samples were annealed in air over the temperature range 300-14000C, their crystal and porous structures as well as the physicochemical and mechanical properties were examined by X-ray and SEM   methods.  The obtained results have revealed that the implant consisted of calcium and phosphate as well as magnesium phosphate and calcium carbonate admixtures. It was characterized by two levels of pores: macropores 300-400 mm in size in the material volume as well as by micro- and transient pores up to 100 nm located over the material surface of the dividing walls. The experiments have supported that in 7-30 –  days at the implant - cortical or spongy bone boundary the muscle and bone tissue gradually germinates into the implant holes. The formation of protein substance in the samples of the calcium-phosphate implants being in contact with the bone for 21 days developed so intensely that it was impossible to separate the implant from the bone, not disturbing its completeness. The developed grafting material is compatible and promotes the bone regeneration process.

 

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Related papers

Presentation: Poster at E-MRS Fall Meeting 2008, Symposium L, by Tatyana M. Ulyanova
See On-line Journal of E-MRS Fall Meeting 2008

Submitted: 2008-05-12 17:22
Revised:   2009-08-10 23:03