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Tissue formation in cellular ceramic scaffolds for motile orbit stump

Vadim Savich 1Oleg L. Smorygo Victoria Krasilnikova Axana Dudich Yury Kovalenko 

1. Research institute of powder metallurgy, Platonova 41, Minsk 220071, Belarus

Abstract

Formation of a motile supporting orbit stump is of special importance for the social rehabilitation of patients who lost the eyeball. Implant material ensuring formation of the stump must meet the following requirements: low weight, high strength-to-density ratio, stability in biological environment, rapid tissue ingrowth and uniting with extraocular muscles. Foam-structure ceramic scaffolds are excellent candidates for this purpose.

In this work the scaffolds were manufactured from alumina-zirconia ceramics via the polyurethane foam replication technology. In some cases a nanocrystalline hydroxiapatite was synthesized and deposited over the scaffold structural elements. The fibro-vascular ingrowth process was studied depending on the scaffold pore size and the availability of the nanocrystallyne hydroxiapatite coating. Materials with optimum parameters were used to manufacture the orbit implants. Results of in-vivo and clinical studies are summarized.
 

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Related papers

Presentation: Poster at E-MRS Fall Meeting 2008, Symposium L, by Vadim Savich
See On-line Journal of E-MRS Fall Meeting 2008

Submitted: 2008-05-12 08:56
Revised:   2009-06-07 00:48