Neuropathic pain is difficult to treat. Classical analgetics, e.g. opioid receptor agonists, possess low activity, therefore other agents, e.g. antidepressants, anticonvulsants or corticosteroids are used.

The changes in pain thresholds were determined using mechanical stimuli - the modification of the classic paw withdrawal test described by Randall-Selitto.

We examined (1) the effect of the opioid receptor agonists on vincristine-induced hyperalgesia and (2) effect of the magnesium ions (Mg²⁺) on antinociceptive action of opioid agonists in toxic neuropathic pain model.

Daily administration of VIN (70 μg/kg, iv) resulted in progressive decrease of pain threshold.

When administered alone opioid agonist like morphine and fentanyl as well as ago-antagonist with potent analgesic activity - buprenorphine had only a little effect on vincristine hyperalgesia. However pretreatment with Mg²⁺ markedly enhanced the analgesic activity of all three investigated opioids. A practical aspect of this phenomenon is discussed.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/14751 must be provided.

1. Effect of selol on the opioids activity in vincristine induced hyperalgesia.