The experiments on drugs acting in females become more common. The complication of interpretation these data is resulted by the estrus cycle. This complexity application of analgesic’s influence on blood pressure in different rat strains.

Antinociceptive action of diclophenac (non-opioid analgesic) was investigated in male and female normotensive (WKY), genetically established hypertensive (SHR) and WAG rats. The aim of this study was the confirmation of the hypothesis regarding fluctuations of blood pressure level during estrus cycle in rat’s female and determination of blood pressure changes after diclophenac treatment.

Diclophenac was administered subcutaneously 10 mg/kg body weight and per os 20 and 40 mg/kg.

Statistically significant differences in pain threshold were reported between male and female rats of investigated strains. Phases of sex cycle in female rats of three strains were determine along with the pain threshold level. Arterial hypertension control in different strains females performed in parallel showed considerable changes in blood pressure after diclophenac administration in the estrous phase. There were several correlated effects in blood pressure and pain threshold after diclophenac administration.

Obtained results may explain the non-uniformity in antinociceptive action of analgetics in both sexes during long-term therapy.

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