“Preliminary study of silicone gel sheets containing onion (Allium cepae) extract for treatment of scars”

Maria E. Żebrowska 1Marzena Jamrógiewicz 2Loretta Pobłocka-Olech 3Jerzy Łukasiak 2Mirosława Krauze-Baranowska 3Małgorzata Sznitowska 1

1. Medical University of Gdańsk, Department of Pharmaceutical Technology, Hallera 107, Gdańsk 80-416, Poland
2. Medical University of Gdańsk, Department of physical chemistry, Gen. J. Hallera 107, Gdańsk 80-416, Poland
3. Medical University of Gdańsk, Department of Pharmacognosy, Gen. J. Hallera 107, Gdańsk 80-416, Poland

Abstract

Hypertrophic scars and keloids are formed during abnormal scarring process and result from excessive collagen deposition. Creams containing onion extract are very common in therapy of the scars and lately occlusive silicone dressings become a popular treatment option. However, the mode of pharmacological action of such preparations still remains unclear.

            Although silicone preparations are used since 1983, there has been no reports about adhesive silicone-based sheet containing any active compounds. Our aim was to develop silicone adhesive gel sheet containing dry onion extract. Another innovative aspect of this project is to use dry onion extract instead of a liquid ethanolic extract, which may allow for introducing higher concentrations of active compounds in the prepared formulation.

            Silicone sheets were formed, using silicone components from Dow Corning (Wiesbaden, Germany) and from Silikony Polskie (Nowa Sarzyna, Poland). Dry onion extract was obtained by spray drying of a liquid ethanolic extract of fresh onion bulbs (Allii cepae bulbus, var. Armstrong).

            The content of quercetin and quercetin glucosides in dry and in liquid ethanolic extracts was compared using high-performance liquid chromatography (HPLC) in order to optimize the method of obtaining onion extract.

            Occlusive properties of prepared silicone gel sheets were examined by measuring the amount of water (50 ºC, 48 h), evaporated from a vial sealed with the studied preparations. Occlusion factors were found to be 60-70 %. Using texture analyser TA XT Plus (Stable Micro Systems, Godalming, Great Britain) it was demonstrated that adhesive properties do not change after washing silicone sheets using warm water with soap, as it is recommended while used by a patient.

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Presentation: Poster at VI Multidyscyplinarna Konferencja Nauki o Leku, by Maria E. Żebrowska
See On-line Journal of VI Multidyscyplinarna Konferencja Nauki o Leku

Submitted: 2008-03-13 14:21
Revised:   2009-06-07 00:48
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