Polyhydroxylated monocarbocyclic derivatives (such as 1 or 2) are known as structures of high biological activity. The bicyclic analogues, houever, although much less known possess also interesting activity. This types of compounds are considered as inhibitors of glycosidase and glycomimics.

Compound 5 has been prepered from the alliltin derivative 4 by a metodology developed in our laboratory [1].

Functionalization of either ring in 5 will be presented a leading example of such functionalization is converrsion of 5 into cyclohexane 6 via Baeyer-Villiger oxidation [2].

[1] Jarosz S.; Gaweł A. Eur. J. Org. Chem. 2005, 3415
[2] Jarosz S.; Nowogródzki M.; Kołaczek M. Tetrahedron: Asymmetry 2007, 2674

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/14616 must be provided.

1. Synthesis of higher carbon sugars. Unexpected rearrangement of higher sugar allylic alcohols
2. Polyhydroxylated decalin derivatives – stereoselective approach from simple sugars via allyltin compounds