Nutrition is a factor of major importance for human health. Nowadays there is no doubts that interactions between genes and nutrients play a key role in health risk prediction and disease prevention. Individual nutritional status is determined not only by food availability, but also by genes that control food intake, nutrient absorption and metabolism. Nutrients can significantly influence gene expression and metabolic processes. Several gene loci have been shown to have a significant impact on the metabolic response to dietary factors. In terms of gene-diet interactions rapid development is observed in the area of cardiovascular disease risk. Polymorphisms in genes coding apolipoproteins, lipolytic enzymes, transfer proteins, fatty acid binding proteins and peroxisome proliferator activated receptors influence changes in lipoprotein metabolism upon dietary interventions.Therefore, genetic variation on metabolic response can explain, at least in part, the individual variability in response to diet and provide a basis for personalized dietary recommendations to promote expression of healthier phenotypes and diminish the risk of development of diet related disorders.

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1. Wpływ diety bogatotłuszczowej i podawania rosiglitazone na profil lipidowy, insulinooporność i stłuszczenie wątroby