Stilbene derivatives appear to be promising chemopreventive agents. One of the most extensively studied is resveratrol, naturally occuring antioxidant found in grapes, wine, an important component of Chinese and Japanese traditional medicine. It has been shown to have a wide range of pharmacological properties. Resveratrol was recently shown to have cancer-chemopreventive activity and to inhibit the growth of a number of human cancer cell lines, however the molecular mechanism of the antitumor action has not been well clarified.

Chemotherapeutic potential of this compound could be related to the ability to arrest the cell cycle progression or trigger cell death by apoptosis. To test this hypothesis, alternations in cell cycle kinetics, proliferation and apoptosis were examined after 12h, 24h, 48h, 72h of incubation MOLT-4 cells with resveratrol. Treatment of MOLT-4 cells with resveratrol at concentration EC₉₀ resulted in cell cycle arrest, apoptosis as revealed by morphological analysis, Annexin V–FITC/PI staining and DNA fragmentation assay. The effect of resveratrol on the ROS production was determined with fluorescent probe H₂DCF-DA.

The results confirmed strong antioxidative and antiproliferative properties of resveratrol.

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