Chlorella algae are recommended by OECD (Organization of Economic Cooperation Development) and other world agencies (EPA, ISO) to investigate influence of chemical matters on aquatic environment, as also estimation of cleanness of waters [1]. Algal tests permit to rate influence on examined chemicals in aquatic environment, one from links of trophic chain. Serve to estimations of biological activity of chemical substances. It is known that quarternary amonium salts are acting on biological microorganisms such as bacteria or fungi and the cytotoxic activity were demonstrated [2]. The aim of present work was comparison of the influence of selected siloxane copolymers with quarternary ammonium groups on growth of alga Chlorella vulgaris cultures. Cultures of Chlorella vulgaris Beijerinck 1890 strain A-8 carried out in 300 ml Erlenmayer flasks with bacteriological corks, in liquid medium Kühl-Lorenzen modified by Borns and others [3], in conditions of continuous lighting with mercury-glow lamp (4800 lx) and continuous mixings with magnetical stirrers. Both cultures, control cultures and cultures with addition of suitable quantities investigated polysiloxane derivatives, such as alpha, omega – trimethyl polysiloxy-{chloric-[3(N-n-octyl-N,N-dimethyl ammonium) propyl}methyl siloxane and alpha, omega-trimethyl polysiloxy-{{chloric-[3(N-n-octyl-N,N-dimethyl ammonium) propyl] ethyl siloxane}-co-(3-chlorpropyl) methyl siloxane}. The initial density of cultures about 300 thousands cells on 1 ml of culture were used in investigations. Observed changes in biological activity of investigated polysiloxanes we can see in growth of Chlorella vulgaris alga cells. The investigated copolymers in heterogeneous manner acts on alga cells. Ascertained changes show univocally that upper named polysiloxanes disturb equilibrium in proliferation and apoptosis process of cells in relation to control cultures. The algicidal effect of these derivatives are different and decide about their quantities, chemical construction and time of acting on algas. [1] OECD Guidelines for the testing of chemicals, Paris 1993. [2] Hoogerheide J.: J. Bacteriol. 1944, 49 (3): 277. [3] Borns E., Böhm H., Schultze D.: Wiss. Hefte d. Päd. Inst. Köthen. 2, 55, 1973.

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