Recently the literary data been indicative on level chanding of liposoluble vitamins, hormones and in pregnant with gestosis the activation of processes of peroxide oxidation of substrata of protein, carbohydrate and lipid metabolism that is accompanied by the accumulation of free radical metabolites which play the leading role in origin of systemic hypoperfusion and hipoxia and cause the development of this complication of pregnancy.

The objective of our study were to investigate vitamino-hormonal status indexes in comparson with the the evidence of endotoxicosis in women in III trimester of pregnancy concerning normal and gestosis of different severity.

In accordance with the objective of study 83 women with gestosis in the different degrees of severity and 48 pregnant women who haven't complication of gestosis were observed. 1-3 groups were formed according to severity of gestosis.

To estimate the activity of antioxidant system in blood plasma it was determined liposoluble antioxidants (A, E) by flowmeter; malon dialdegyd (MDA) spectrophotometrically. The content of estradiol, cortisol was determined by the radioimmunological methods. Level an endotoxicosis was estimated by calculation of leukocytic intoxication index (LII).

The intensity of systemic oxidant stress in the late stages of gestosis registered by dynamics of plasmic level of three interactive indexes (vitamins A, E and МDА), as well as hormones was changed depending on degrees of severity in the late stages of gestosis. Pregnant women with gestosis developed incresing of MDA in contract to normal pregnancy. Only womans of second group was showed it’s increasing in 33%. In the first and second group of woman the content of vitamin A, E and cortisol was higher than in control, and the content of estradiol was low in comparison with physiologically running pregnancy. In the third group the content retinol and cortisol was higher than in control and the content of estradiol was lower in 56%. On the grounds of obtained fingings we can suppose that the redundant content in of lipid peroxides leed to increasing outlet of tocoferol and retinoids into blood from tissues. Tissue deficiency in antioxidants accelerates formation of peroxides and contributes to desorganization of cell metabolism and main cell functions. A vicious cicle has been locked, which was supported by hormonal disbalance. In calculation of LII it was revealled it was 1,0 0,1 units in healthy women and in gestosis of light, mild and severe degrees it was in average about 1,2±0,1 (p>0,05); 1,70,2 (p<0,05); 2,6±0,3 (p<0,001) units accordingly. This is due to reducing of eosinophil number (some women had aneosinopenia) and increasing an amount of stab and nucleosegmental neutrophils in women with gestosis.

Thus, obtained results help to consider exchange indexes of vitamins, hormons in blood plasma, accounting indexes of endogenous intoxication as additive criteria, characterizing degree of the evidens in gestosis.

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