The chair of obstetrics and gynaecology of Grodno state medical university*, the chair of physiology of Grodno state agrarian university **, the department of clinical laboratory diagnostics of Grodno regional clinical hospital***

Scientific literature has the proofs of the use of breast milk for evaluation of vitamin and hormonal status of nursing mothers. Though in this biological liquid it was not possible to determine the levels of activity of hepatocyte enzymes, by means of which it is a possible to evaluate the functional condition of the liver in the organism of a nursing mother.

48 healthy puerperas and 83 having preeclampsia of different degrees of severity during pregnancy were examined to evaluate the activity of enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDG) in blood serum and breast milk) on the 3rd day of post natal period using automatic biochemical analyzer “Architect C8000” by ABBOTT (USA).

The activity of enzymes, digitally determined in breast milk is the same to the activity of enzymes in blood serum. It was revealed the direct correlation dependence between studied indices (for ALT correlation coefficient made up r=+0,85; for AST r=+0,87; for LDG r=+0,810). It was discovered the increase of activity of all examined enzymes according to the level of preeclampsia severity: the activity of ALT made up more then 50,0 Unit/l, AST – more then 47,5 Un/l, LDG – more then 316 Un/l and correlated with clinical presentations of liver lesion (pain in right hypochondrium and epigastric area) that puerperas suffered from preeclampsia had.

Thus noninvasive method of evaluation of liver function of nursing mothers in post natal period is effective, informative and safe in comparison to the traditional one.

The use of breast milk for noninvasive evaluation of liver function by means of determination of activity of hepatocyte enzymes creates the possibility for manifold research, preservation of peripheral veins for subsequent intravenous introduction of medical products, save the time of laboratory assistants and hospital nurses while receiving biological samples, prevent infectious complications and appearance of stress reaction while receiving biological samples.

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