The ZAC gene encodes a novel zinc finger protein that regulates apoptosis and cell cycle arrest and maps to chromosome 6q24-q25, a region known to harbor putative tumor suppressor genes frequently involved in solid cancer tumors. ZAC shares a number of similar functions to p53 tumor suppressor, and Zac protein is thought to act synergistically with the p53 in causing apoptosis, possibly by co-activation of p53 target genes. The purpose of this study was to investigate the expression of ZAC gene in bladder cancer samples using real-time RT-PCR technique. ZAC expression was measured in 26 frozen neoplastic and adjacent non-neoplastic tissues, paired of each patient. The analysis revealed that ZAC mRNA expression was reduced in 24 of 26 (92%) cases of bladder cancer. Greater decrease of the ZAC mRNA expression was observed in superficial (Ta/T1) tumors comparing with muscle invasive (T2-T4) bladder tumors. The altered expression of ZAC support the gene's potential role in the pathogenesis of bladder cancer. These results indicate that the decreased expression of ZAC gene is a very common and early event in bladder cancer.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/10917 must be provided.