Here we reported the cytotoxic and apoptosis inducing activity of lipophilic flavones fraction, isolated from leaves of Primula Veris from field cultivation (U3) and obtained by in vitro propagation (iv2), on HeLa and HL 60 cell lines wild type and two multidrug resistant sublines HeLa MDR1 and HL 60 AR. To assess the sensitivity of cells the MTT test was used. We observed the differences in the sensitivity of these cell lines to the lipophilic flavones. These results suggest higher sensitivity of promyelocytic cells comparing to epitheloid carcinoma to both lipophilic flavones fractions.

In addition we showed that multidrug resistant subline HeLa MDR1 and HL 60 AR exhibited resistance to studied extracts. The level of resistance to the U3 and iv2 seems to be associated with multidrug resistance caused by overexpression of MDR1 and MRP genes. More detailed studies showed that the component of the tested plant extract, zapotin seems to have a modulating influence on MRP1 protein.

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