The glucolysis activity has been studied in rat liver after acute alcohol intoxication. The i. p. ethanol administration in the dose of 1 g/kg of body weight led to decrease in the hexokinase (HK) and glucokinase (GK) activities by 29% (p< 0.02) and 34% (p< 0.001) compared to control. At that time the piruvate kinase (PK) was lower in the ethanol treated group, and the phosphofructokinase (PFK) and lactate dehydrogenase (LDH) activity didn't change compared to the control group. The i. p. ethanol administration in the dose of 2.5 g/kg caused the inhibition of PFK and the activation of LDH, and might indicate the activation of anaerobic glucolysis in liver. The ethanol administration in the toxic dose of 5 g/kg resulted in the reliable inhibition of all limiing glucolytic enzymes. The HK activity was lower by 35% (p< 0.001), the GK activity decreased by 37% (p< 0.001), the PFK activity decreased by 28% (p< 0.02), the PK activity decreased by 32% (p< 0.01). The changes might suggest the slowing down of glycolitic processes in liver, followed by the reliable activation of LDH and increase in the lactate content.

Therefore the changes in the glycolisis functioning in liver were dependent upon the doses of ethanol administered and were higher after the highest dose administration.

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