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Decrease of serum protein carbonyl groups after vertical banded gastroplasty in obese patients.

Tomasz Śledziński 1,  Elżbieta Goyke 2

1. Department of Pharmaceutical Biochemistry, Medical University of Gdańsk, Gdańsk 80211, Poland
2. Department of Biochemistry, Medical University of Gdańsk, Gdańsk 80211, Poland

Abstract
Obesity is associated with high oxidative stress. Vertical banded gastroplasty is a surgical treatment undertaken in order to reduce body weight in pathological obesity. It has been reported that gastroplasty leads to decrease of body mass of obese patients as well as to decrease of MDA concentration, oxidized LDL level and to increase of α-tocoferol concentration in blood. The aim of the study was to investigate the effect of surgically induced weight loss on serum protein carbonyl groups level. Protein carbonyl groups were quantified by reaction with 2,4-dinitrophenylhydrazine in serum collected from 10 obese patients before and 6 months after surgery, and from 10 control nonobese persons. Serum protein carbonyl groups levels of obese patients before surgery was about 50% higher than in control nonobese persons. Vertical banded gastroplasty resulted in significant reduction of serum protein carbonyls, to the level similar to control nonobese persons. Moreover serum leptin concentration decreased after surgery, that could be one of the reasons for reduction of oxidative stress. These results suggest that vertical banded gastroplasty leads to decrease of systemic oxidative stress.

 

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Presentation: Poster at Zjazd Polskiego Towarzystwa Biochemicznego, Sympozjum M, by Tomasz Śledziński
See On-line Journal of Zjazd Polskiego Towarzystwa Biochemicznego

Submitted: 2007-04-26 13:22
Revised:   2009-06-07 00:44