dr Andrzej J. Bojarski

Affiliation:

Polish Academy of Sciences. Institute of Pharmacology

Participant:

V Multidyscyplinarna Konferencja Nauki o Leku

Participant:

VI Multidyscyplinarna Konferencja Nauki o Leku

Participant:

VII Multidyscyplinarna Konferencja Nauki o Leku

Publications:

1. 2-(1-Arylsulfonylpiperidin-2-yl)ethyl derivatives as 5-HT₇ receptor ligands: synthesis and their affinity for 5-HT_1A/5-HT_2A/5-HT₇/D₂ receptors
2. 8-ALKOXY-PURINE-2,6-DIONES WITH 7-PHENYLPIPERAZINYLALKYL AND 7-TETRAHYDRO-ISOQUINOLINYLALKYL MOIETIES AS 5-HT_1A, 5-HT_2A, 5-HT₇ RECEPTOR LIGANDS
3. Alkyl-nitroquipazine derivatives as serotonin transporter and 5-HT_1A receptor ligands
4. CHO cell line with stable expression of the HTRA1 gene as a tool for studying functional activity of 5-HT_1A receptor ligands
5. Crystal structure of β-adrenergic receptor as a new template in homology modeling of GPCR. Application to serotonin 5-HT_1A and 5-HT₇ receptors
6. DESIGN AND SYNTHESIS OF NEW 7-PHENYLPIPERAZINYLALKYL AND 7-TETRAHYDROISOQUINOLINYLALKYL DERIVATIVES OF PURINE-2,6,8-TRIONE AS POTENTIAL SEROTONIN RECEPTOR AGENTS
7. Examination of 5-HT₆ receptor affinity in the group of arylsulfonamide derivatives
8. Homology modeling of G-protein coupled receptors
9. Identification of Novel 5-HT₇R Ligands via Multistep Virtual Screening of Commercially Available Compounds Databases
10. Interaction fingerprints patterns. Binding mode analysis of mGlu2 receptor model based on docking studies
11. Ligand-directed receptor trafficking
12. Mannich bases, 5-arylimidazolidine-2,4-dione derivatives with arylpiperazine moiety, as 5-HT_1A receptor ligands with serotonin transporter affinity
13. Molecular modeling explains differences in binding affinity of new potent and selective 5-HT_1A ligands: arylpiperazinylalkylthiobenzoxazole derivatives
14. NEW DUAL 5-HT₇/5-HT_1A LIGANDS WITH ANTIDEPRESSANT AND ANXIOLYTIC-LIKE ACTIVITY
15. New serotonin receptors ligands in the group of 8-acylamide derivatives of 1,3-dimethyl-7-[(4-phenyl- piperazin-1-yl)-alkyl]-1H-purine-2,6-(3H,7H)-dione
16. Quinolinesulfonamides as potential 5-HT₇ and 5-HT_1A receptor ligands
17. Rational design and synthesis of new 5-HT₆R ligands with the use of bioisosteric strategies. Crystal structures, biological evaluation and molecular modeling studies.
18. SAR studies of novel 5-HT₇R ligands with different spacers between aryl and amine moieties
19. Searching for lead molecules as potential new CNS agents in the serotonin 5-HT₆ screening assay
20. Serotonin transporter inhibitors inducing hypothermia at mice
21. Solid-phase synthesis and preliminary biological investigation of arylpiperazine library as 5-HT_1A and 5-HT_2A receptor ligands
22. Synthesis and serotonin receptors activity of new purine-2,6-dione derivatives with arylpiperazinylalkoxy moieties
23. Synthesis, anticonvulsant activity and 5-HT_1A/5-HT₇ receptors affinity of new 1-[(4-substituted-  piperazin-1-yl)-alkyl]- 3-methyl- 3-(2-methylpropyl)-pyrrolidine- 2,5-diones
24. Synthesis of long-chain arylpiperazine theophylline derivatives as potential 5-HT₇ and 5-HT₆ receptors ligands
25. Synthesis of novel pyrido[1,2-c]pyrimidine derivatives as selective ligands for 5-HT_1A receptors
26. THE BIOLOGICAL TARGET DERIVED PHARMACOPHORIC MODEL FOR 5-HT₇ SEROTONIN RECEPTOR ANTAGONISM
27. The ligand binding to the serotonin transporter
28. The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of arylxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists