Organic compounds containing aromatic heterocyclic rings have received considerable attention among medicinal chemists because many of them play a role in various biochemical processes. 1,2,4-Triazole and morpholine derivatives belong to an aromatic heterocyclic group exhibiting a wide range of biological activities, such as antimicrobial and anti-inflammatory.

In general, 3,4-disubstituted-1,2,4-triazole could be prepared by the intramolecular dehydrative cyclization of 1,4-disubstituted thiosemicarbazides.

In our experiments the hydrazide of 3-(morpholin-4-yl)propionic acid was used as a starting material for the preparation of thiosemicarbazide derivatives 1a-1d. Next, cyclization of these compounds led to new compounds 2a-2d with a promising pharmacological activity.

The structure of all new compounds was confirmed by elemental analysis, as well as by the IR, and ¹H NMR spectra.

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