Compounds with 1,2,4-triazole moiety have received considerable attention among medicinal chemists because molecules with this structural feature have been found to display a wide range of potent biological activities, such as antifungal, antibacterial, antiviral, anti-inflammatory and antitumor. One of the method to synthesize these compounds is the reaction of condensation of amidrazone hydrochlorides with isothiocyanates. The above method was applied to synthesis of ethyl ester of 1,3-diphenyl-1,2,4-triazoline- 5-thione-4-acetic acid 1, which was next used to prepare new compounds by transformation in the ester group. Thus, 1 was transformed first into the corresponding hydrazide 2 and then into the respective thiosemicarbazides 3. Next, the base or acid catalyzed intramolecular dehydrative cyclization of 3 furnished compounds 4 composed of two 1,2,4-triazoles linked through the methylene group or compounds 5 consisting of 1,2,4-triazole and 1,3,4-thiadiazole linked in the same way.

Compounds with the similar structure show a weak toxicity and have sedative activity. We expected that new analogues also could have sedative activity on the central nervous system.

The structures of the new compounds were established by the elemental analysis, infrared and nuclear magnetic resonance data.

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2. Fungal N-myristoyltransferase as potential target for thiosemicarbazide-based compounds
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4. The antiviral and virucidal activity of novel 2-[(4-methyl-4H-1,2,4-triazol-3-yl) sulfanyl]acetamide derivatives
5. Synthesis, antimicrobial, and pharmacological properties of thiadiazole derivatives
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9. ANTIMICROBIAL ACTIVITIES OF 4-SUBSTITUTED 3-(PIPERIDIN-4-YL)-Δ²-1,2,4-TRIAZOLINE - 5 - THIONES
10. REACTIONS OF 3-(MORPHOLIN-4-YL)PRO- PIONIC ACID HYDRAZIDE WITH ISOTHIOCYANATES
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