Chitosan-Silver Nanocomposites: synthesis, characterization and antibacterial activity against Staphylococcus aureus

Anna Regiel-Futyra 1Agnieszka Kyzioł 1Grażyna Stochel 1Manuel Arruebo 2Jesus Santamaria 2

1. Jagiellonian University, Faculty of Chemistry, Ingardena 3, Kraków 30-060, Poland
2. Instituto de Nanociencia de Aragon, Universidad de Zaragoza (INA), Pedro Cerbuna 12, Zaragoza 50009, Spain

Nowadays, there is a great interest in development of bionanomaterials exhibiting antibacterial activity against multi-drug resistant bacterial strains. Appearance of antibiotic resistant ones has moved the researchers attention to searching for new alternative bactericidal agents, which could possibly replace so popular antibiotics. Despite the discovery of a various active agents, very few exhibit desirable properties as biocompatibility, biodegradability and non-toxicity. Among a number of nanotechnological strategies, fabrication of polymer-metal nanoparticles bionanocomposites draws a lot of attention1, 2.


The present investigation concerns chitosan-silver nanocomposites fabrication, physicochemical characterisation and their antibacterial activity evaluation against two Gram-positive, biofilm forming bacterial strains Staphylococcus aureus.


Chitosan, biocompatible and biodegradable polymer was used as a reducing and stabilizing agent in the optimized silver nanoparticles synthesis. Nanoparticles and nanocomposites were characterized by UV-vis, IR, TGA, SEM, TEM, etc. techniques. Obtained nanoparticles, trapped in the polymeric network showed high antibacterial activity against biofilm forming S. aureus and caused significant morphological changes in the bacterial cell walls (Fig.1).

Fig.1. Chitosan based silver nanoparticles (<10 nm), revealing high bactericidal activity against S. aureus.


(1)     Vimala, K.; Mohan, Y. M.; Sivudu, K. S.; Varaprasad, K.; Ravindra, S.; Reddy, N. N.; Padma, Y.; Sreedhar, B.; MohanaRaju, K., Colloids and Surfaces B: Biointerfaces 2009, 76, (1), 248-258.

(2)     Thomas, V.; Yallapu, M. M.; Sreedhar, B.; Bajpai, S. K., Journal of Biomaterials Science, Polymer Edition 2009, 20, (14), 2129-2144.


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Presentation: Poster at Nano-Biotechnologia PL, by Anna Regiel-Futyra
See On-line Journal of Nano-Biotechnologia PL

Submitted: 2012-06-28 13:41
Revised:   2013-02-13 17:40
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