The quinoline moiety can be considered as privileged structure (1). It is present in many synthetic drugs and natural products with spectrum of activity covering antifungal, anticancer and antiviral effects(2-3). Nevertheless bioeffectors designed on the core of quinoline moiety still suffers from poor bioavailability/membrane transport. This prompted us to incorporate biologically relevant sugar scaffold into some quinoline related biomolecules.

The example of synthesized compound

Sugar part could be mono- or oligosaccharide connected to quinoline derivatives by amide, ester, thioester or glycosidic bond. Choice of sugar part structure was caused by earlier performed researches (4-5).

Obtained structures and their expected and examined biological activity will be presented. Moreover all synthesized compounds are part of  the novel Polish Patent Application (2012).

Research studies are part-financed by Ministry of Science and Higher Education of Poland (Grant No. N N209 186338). Maciej Serda was supported by a TWING fellowship and NCN grant DEC-2011/01/N/NZ4/01166.

(1) Musiol, R.; Serda, M.; Hensel-Bielowka,S.; Polanski, J.; Current Medicinal Chemistry, 2010, 17,1960-73;

(2) Musiol, R.; Jampilek, J.; Buchta, V.; Silva,L.; Niedbala, H.; Podeszwa, B.; Palka, A.; Majerz- Maniecka, K.; Oleksyn, B.; J.Polanski; Bioorganic & Medicinal Chemistry, 2006, 14, 3592-98;

(3) Majerz-Maniecka, K.; Musiol, R.; Skórska-Stania, A.; Tabak, D.; Mazur, P.; Oleksyn, B. J.; Polanski, J.; Bioorganic & Medicinal Chemistry, 2011, 1606-1612;

(4) Pastuch-Gawolek, G.; Bieg, T.; Szeja, W.; Flasz, J.; Bioorganic Chemistry, 2009, 37, 77-83;

(5) Pastuch, G,; Komor, R.; Grec, M.; Szeja, W.; Acta Poloniae Pharmaceutica – Drug Research, 2010, 67, 642-651.

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