Molecularly imprinted polymer (MIP) chemosensors for surface plasmon resonance (SPR) and differerntial pulse voltammetry (DPV) determination of melamine

Marta Sosnowska 1Tan-Phat Huynh 1Agnieszka Pietrzyk-Le 1Raghu Chitta Francis D'Souza 2Wlodzimierz Kutner 1

1. Polish Academy of Sciences, Institute of Physical Chemistry, Kasprzaka 44/52, Warszawa 01-224, Poland
2. University of North Texas (UNT), 3940 N. Elm, Denton 76207, United States


Melamine is a small molecule, amine that is illegally used to artificially increase protein reading in dairy products [1]. Long-term exposure to melamine may cause formation of lethal kidney stones in humans [2]. Preparation of molecularly imprinted polymer (MIP) film sensitive to melamine and its integration with a piezomicrogravimetric sensor by means of electropolymerization has already been reported [3]. In the presented work, the previously synthesised functional and cross-linking monomers were used to prepare a recognition unit for the surface plasmon resonance (SPR) and differential pulse voltammetry (DPV) chemosensors. Parameters of the MIP preparation, like composition of the solution for electropolymerization, the type of solvent used for template extraction, and film thickness, were optimized in order to obtain a recognition film with appreciable both the limit of detection and the dynamic linear concentration range for melamine determination. Thickness of the MIP film was measrued using spectroscopic ellipsometry and atomic force microscopy. The limit of detection reached the range of tens of micromoles and nanomoles, and the linear concentration range attained the level of milimoles and nanomoles for SPR and DPV, respectively.


[1] E. L. Bradley, V. Boughtflower, T. L. Smith, D.R. Speck, L. Castle, Food Addit. Contam. 2005, 597.

[2] R. L. Dobson, S. Motlagh, M. Quijano, R. T. Cambron, T. R. Baker, A. M. Pullen, B. T. Regg, A. S. Bigalow-Kern, T. Vennard, A. Fix,  Toxicol Sci, 2008, 251.

[3] A. Pietrzyk, W. Kutner, R. Chitta, M. E. Zandler, F. D’Souza, F. Sannicolo, P. R. Mussini, Anal. Chem. 2009, 10061.

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Presentation: Poster at SMCBS'2011 International Workshop, by Marta Sosnowska
See On-line Journal of SMCBS'2011 International Workshop

Submitted: 2011-10-21 15:12
Revised:   2011-10-27 15:53
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