Phospholipids are the primary constituent in lipids bilayer structures, and are used in the construction of biomimetic interfaces.  The physical deposition of lipid bilayers on planar substrates results in structures that are not physically robust, and there have been a variety of methods used to bind lipids to interfaces.  In this talk I will describe some of the recent efforts of my research group in forming self-assembled lipid bilayer structures, where the lipids are bound chemically to the interface.  This strategy can be used on either metallic or dielectric interfaces, depending on the binding chemistry used.

One method of lipid binding we will discuss are covalent bonding of lipids to metallic substrates using thiol/gold chemistry, and the limits imposed on this approach by the morphology of liposomes used in the deposition process.  Another method is the use of metal-phosphate complexation chemistry on surfaces that have been modified to produce a phosphate-terminated interface.  These methods result in interfaces with different physical properties, which we will discuss.

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1. Organization and Dynamics within Supported Interfaces:  Implications for the Creation of Biomimetic Structures
2. Triple Phase Boundary Photo-Voltammetry: Resolving Rhodamine B Reactivity in 4-(3-Phenylpropyl)-Pyridine Microdroplets
3. Understanding and Controlling Curvature and Intermolecular Interactions in Biomimetic Membranes
4. Probing interfacial organization in planar lipid bilayers using tethered pyrene
5. Immobilization of molecules: From self-assembled monolayers to polymeric hollow structures
6. Probing organization and communication at layered interfaces
7. Design, Synthesis and Characterization of Monomolecular Interfacial Layers