Strategies for Self-Assembly of Phospholipids at Interfaces

Monika J. Dominska ,  Benjamin P. Oberts ,  Gary J. Blanchard 

Michigan State University, Department of Chemistry (MSU), East Lansing, MI 48824, United States

Abstract

Phospholipids are the primary constituent in lipids bilayer structures, and are used in the construction of biomimetic interfaces.  The physical deposition of lipid bilayers on planar substrates results in structures that are not physically robust, and there have been a variety of methods used to bind lipids to interfaces.  In this talk I will describe some of the recent efforts of my research group in forming self-assembled lipid bilayer structures, where the lipids are bound chemically to the interface.  This strategy can be used on either metallic or dielectric interfaces, depending on the binding chemistry used.

One method of lipid binding we will discuss are covalent bonding of lipids to metallic substrates using thiol/gold chemistry, and the limits imposed on this approach by the morphology of liposomes used in the deposition process.  Another method is the use of metal-phosphate complexation chemistry on surfaces that have been modified to produce a phosphate-terminated interface.  These methods result in interfaces with different physical properties, which we will discuss.

 

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Presentation: Tutorial lecture at SMCBS'2009 International Workshop, by Gary J. Blanchard
See On-line Journal of SMCBS'2009 International Workshop

Submitted: 2009-08-27 13:03
Revised:   2009-08-27 13:03