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Nanotechnology for Improving Implant Function

Thomas J. Webster 

Brown University, Providence, RI 02912, United States

Abstract

Nanotechnology is being used to mimic structural components of our tissues in synthetic materials intended for various implant applications. Recent studies have highlighted that when compared to flat or micron rough surfaces, surfaces with nanofeatures promote optimal initial protein interactions necessary to mediate cell adhesion and subsequent tissue regrowth. This has been demonstrated for a wide range of implant chemistries (from ceramics to metals to polymers) and for a wide range of tissues (including bone, vascular, cartilage, bladder, and the central and peripheral nervous system). Importantly, these results have been seen at the in vitro and in vivo level. This talk will cover some of the more significant advancements in creating better bone and cartilage implants through nanotechnology efforts. It will also cover recent in vitro and in vivo studies which highlight better bone and cartilage regeneration. Advancements made in understanding possible toxic effects of nanomaterials for these tissues will also be discussed.

 

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Related papers

Presentation: Invited at E-MRS Fall Meeting 2007, Acta Materialia Gold Medal Workshop, by Thomas J. Webster
See On-line Journal of E-MRS Fall Meeting 2007

Submitted: 2007-06-25 17:34
Revised:   2009-06-07 00:48