About fifty percent of patients presenting acute coronary syndrome who does not display classical risk factors, remain inaccessible for prevention. Plasma hsCRP and ischemia modified albumin (IMA) were recently introduced as more informative cardiovascular risk markers. The intracellular bacterium Chlamydia pneumoniae is involved in the inflammation process of atherosclerosis. Aim of study was to assess the relation between C. pneumonie infection, plasma hsCRP and IMA level and oxidative stress/antioxidant plasma capacity. Methods. A total of 83 men included in the study consisted of: cardiovascular event-free obese (BMI >30; < 35kg/m2) men (O) without others CHD risk factors, and the control group (C) of healthy subjects. The lipoprotein profile, plasma hsCRP, IMA, markers of oxidative stress, antioxidant plasma capacity, and C.pneumoniae antibodies were measured. Results. Plasma hsCRP and IMA/alb directly correlated with the body fat in whole group. Examination of high score IMA/alb ratio and hsCRP patients compared to reference group revealed low antioxidant level, oxidative alteration of LDL, higher plasma content of LOOH, TBARS, and reduced redox compensation index. Percentages of subjects from C and O groups positive for C.pneumoniae antibodies were associated with IMA/alb ratio in the highest group quartile. Markedly decreased plasma antioxidant capacity and increased oxidative stress characterized antibody-positive subjects. Conclusion: Plasma hsCRP, C.pneumoniae antibody index as well as IMA score may serve as potential marker of oxidative stress and low antioxidant status.

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