prof Jerzy Konopa

Publications:

1. Antitumor triazoloacridinone C-1305 as a potent FLT3 tyrosine kinase inhibitor in human leukemia MV4;11 cells.
2. Effects on cell cycle distribution and induction of apoptosis of human breast carcinoma MCF7 cells by imidazoacridinone C-1311
3. Imidazoacridinone antitumor agent, C-1311, as a selective mechanism-based inactivator of human recombinant cytochrome P450 1A2.
4. METABOLIC TRANSFORMATIONS OF ANTITUMOR AGENTS WITH CYTOCHROME P-450 ISOENZYMES.
5. Metabolism of antitumor 9-amino-1-nitroacridine derivative C-1748 (Capridine-beta) in human hepatoma HepG2 cells
6. The cellular response of human colon carcinoma HCT116 cells to 4-methyl-1-nitroacridine derivative C-1748 treatment depending on p53 status.
7. The cellular response of human hepatoma cells with different expression of cytochrome P450 isoenzymes to treatment with acridine derivatives
8. The role of Cytochrome P450 Reductase in metabolism of potent nitroacridine antitumor agent, C‑1748.
9. The role of hepatic cytochrome P-450 enzymes in metabolism of imidazoacridinone antitumor agent, C1311 (Symadex^R): studies with the hepatic NADPH:cytochrome P450 reductase null mice