Surface functionalization and activation of biomaterials
Over the last 15 years, biomaterials research is oriented to the activation of biomaterial surfaces in order to optimise tissue integration of medical devices. At the present state-of-the-art, functionalization is turning around the grating of polyacrylic acid or polyethylene glycol as spacer molecules for further binding of bioactive molecules such as extracellular matrix constituents, but without any eminent progress. - Since now about 5 years several laboratories have enhanced their competences to develop new technologies in order to obtain biocompatible materials with functionalised surfaces. Several means are available in particular the grafting of bioactive molecules (i) via new spacer molecules to stimulate the target to go to the material surface, and (ii) via cage molecules to provide controlled drug delivery systems. Most of these methods can be applied on all implantable materials, and they are in particular very useful and forthcoming for scaffolds, hybrid medical devices and tissue engineering.
The aim of this symposium is to generate more scientific and industrial co-operation between technical, biological and medical domains. It will subsequently largely be open to researchers from multiple disciplines such as material science and engineering, mineral and organic chemistry, (bio)physics, electro-chemistry, analytics, cell and molecular biology, pharmacology, medicine (orthopaedics, dentistry, ophthalmology, cardiology, urology, visceral surgery).
This symposium will cover wide multidisciplinary fields from Material Science (metals, ceramics, polymers), Surface Physico-chemistry, Cell Biology, Biochemistry, Macromolecular Chemistry to achieve the improvement of interface interactions and subsequently of tissue integration of medical devices.The main topics of the symposium will be:
L. BORDENAVE (France), M. CREPIN (France), K. DE GROOTE (Netherlands), Q. L. FENG (China), D. GRANT (U.K.), V. HARABAGIU (Romania), U. M. LOSERT (Austria), Y. H. KIM (Korea), C. J. KIRKPATRICK (Germany), O. MELNYK (France), C. MIGLIARESI (Italy), M. MORCELLET (France), J. RYCHLY (Germany), B. C. SIMIONESCU (Romania), M. TEXTOR (Switzerland), Y. M. ZHAO (Chine), G. ZIEGLER (Germany).
Hartmut F. HILDEBRAND
Directeur de Recherche INSERM
Groupe Recherche Biomatériaux
Laboratoire de Biophysique UPRES EA 1049
Faculté de Médecine "H. Warembourg"
1, place de Verdun
59045 LILLE cedex