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An in vitro study of polymer based composites

Bozena D. Konieczna 2Marta Blazewicz 2Barbara Czajkowska 1

1. Jagiellonian University, Department of Immunology (UJ), Kraków, Poland
2. AGH University of Science and Technology, Department of Biomaterials (AGH-UST), Al. Mickiewicza 30, Kraków 30-059, Poland

Abstract

Most of the tissues existing in human body have structures, which can be simulated with fibrous composite materials. The main problem associated with designing biocompatible composites for reconstruction of damaged or missing tissues is the ability of mimicking such structures. Physical, chemical and mechanical properties of composite materials should be similar to those of the native tissues. Another very important property of polymer-based fibrous composite materials, which can relatively easily be modified, is their surface microstructure. This surface microstructure depends on the way of preparation, type of polymer matrix and kind of reinforcement used.
This work aimed at determination of biological properties of composites obtained from carbon fibres and polymer matrix, which could possibly be utilised as implant materials in reconstruction of cartilage tissue. Two types of samples based on short carbon fibres, differ with polymers were tested. The samples were prepared by casting technique. MTT tests were carried out in the presence of hFOB-1.19-line human osteoblasts and HS-5-line human fibroblasts. The results show differences in viability of living cells.
These results suggest that if biocompatibility of polymer-based fibrous composites could be achieved then their possible use as implant material could be considered feasible and shall consequently be investigated.

 

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Presentation: poster at E-MRS Fall Meeting 2003, Symposium E, by Bozena D. Konieczna
See On-line Journal of E-MRS Fall Meeting 2003

Submitted: 2003-05-27 20:42
Revised:   2009-06-08 12:55