Recently we described synthesis and biological activity of several cyclic opioid analogues which contained N-terminal sequence of enkephalin and the common sequences for dermorphin and deltorfin [1,2,3]. These peptides, containing only the "messeage sequences" of natural peptide showed very high dual agonist potency in the GPI and MVD assays.

In this report we present synthesis and biological activity of peptides containing also "address sequence" for dermorphin (A) and deltorfin (B). Also, enkephalin sequence was elongated by alkylurea unit.

References:

[1] D. Pawlak, M. Sidor, J. Wójcik, M. Pachulska, N.N. Chung, P.W. Schiler, J. Izdebski, J. Peptide Sci., 2001, 7, 128-140.

[2] K. Filip, M. Oleszcuk, D. Pawlak, J. Wójcik, N.N. Chung, P.W. Schiller, J. Izdebski, J. Peptide Sci., 2003, 9, 649-657.

[3] K. Filip, M. Oleszczuk, J. Wójcik, N.N. Chung, P.W. Schiller, D. Pawlak, A. Zieleniak, A. Parcińska, E. Witkowska, J. Izdebski, J. Peptide Sci., 2005, 11, 347-352.

This work was supported by the Polish State Committee for Scientific Research (Grant No. 3T09A 02328)

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