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MOBILE PHASE INFLUENCE ON CHROMATOGRAPHIC BEHAVIOUR OF SOME 1,4-DISUBSTITUTED PIPERAZINES

Anna Jończyk 1Małgorzata Lisowska Kuźmicz 1Hanna Ksycińska 2Maria Mazgajska 2Zdzisław Chilmonczyk 1

1. Narodowy Instytut Zdrowia Publicznego, Chełmska 30/34, Warszawa 00-725, Poland
2. Pharmaceutical Research Institute (IF), Rydygiera 8, Warszawa 01-793, Poland

Abstract

Chromatographic behaviour of several 1,4-disubstituted piperazine derivatives on cellulose and amylose chiral stationary phases as well as mobile phase influence on solute-stationary phase complexes have been examined. The influence of hydrophobic aliphatic substituents appeared to be much stronger on cellulose than on amylose phase. Also mobile phase influence exhibited pronounced differences. For isopropanol-hexane mobile phases higher solute-stationary phase complex stabilities on cellulose than on amylase stationary phase were observed. On the other hand, on cellulose stationary phase in isopropanol-hexane mixtures the complex stabilities were bigger than in ethanol-hexane mixtures, while on amylose different relationship was observed. The significance of the obtained results will be discussed.

 

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Presentation: Poster at V Multidyscyplinarna Konferencja Nauki o Leku, by Anna Jończyk
See On-line Journal of V Multidyscyplinarna Konferencja Nauki o Leku

Submitted: 2006-02-01 12:00
Revised:   2009-06-07 00:44