THE CYTOTOXIC GLYCOSIDES OF INDOLO[2,3-B]QUINOLINE DERIVATIVES. IN VITRO AND IN VIVO STUDIES
|Aleksandra Nowicka 1, Małgorzata Piskozub 1, Joanna Wietrzyk , Katarzyna Badowska-Rosłonek 2, Łukasz S. Kaczmarek 2, Wanda Peczyńska-Czoch 3|
1. Polish Academy of Sciences, Institute of Immunology and Experimental Therapy (IITD), Rudolfa Weigla 12, Wrocław 53-114, Poland
The cytotoxic activity in vitro of glycosides of indolo[2,3-b]guinoline having daunosamine or acosamine moiety was evaluated. In our research we used human colon cancer (LoVo), uterine sarcoma (MES-SA), promyelocytic leukemia (HL-60), lung cancer (A-549) and melanoma (Hs294T) cell lines. We found that all the indoloquinolines studied were cytotoxic against the cells of all cancer lines used. They showed the highest cytotoxic activity against human leukemia cell line (HL-60) and the lowest against the human melanoma cell line (Hs294T) as well as against the human colon cell line (LoVo) (Table1.)
To define antitumor activity the compound IBR-5 in vivo we applied mouse leukemia cell line (P-388). The results of our research show toxicity of studied compound in higher range of doses (30, 50 and 100 mg/kg). The average survival time (AST) of mice, which was administered with the compound IBR-5 in higher doses was 7 days and for control mice 12 days. Additionally in lower range of doses (10, 5, 1 mg/kg) the compound did not show antitumor effect. The average survival time of mice which were administered with the compound in lower doses was comparable to AST of control mice.
Presentation: Poster at V Multidyscyplinarna Konferencja Nauki o Leku, by Aleksandra Nowicka
See On-line Journal of V Multidyscyplinarna Konferencja Nauki o Leku
Submitted: 2006-02-01 07:30 Revised: 2009-06-07 00:44